Manchester United's Luke Shaw suffers concussion on England duty

An injury to Shaw at the start of the second half led to a lengthy delay, with the Manchester United fullback withdrawn on a stretcher following a heavy collision with Carvajal, to be replaced by Danny Rose.

De Gea produced an acrobatic save to dent Rashford a second goal shortly afterwards but Spain ended the half on top.

Gareth Southgate also weighed in on Shaw's injury after the match, saying the team wouldn't take any chances as he continues treatment.

"We know in the back of our minds that there is a lot of hard work to do from now until the Euros to first get there and then hopefully go even further than we did at the World Cup", Kane said.

Despite his satisfaction with the result, which came courtesy of Rodrigo's decisive goal before half-time, Luis Enrique told his players to look ahead to their next Nations League match against World Cup finalists Croatia rather than dwell on the victory.

At home, England is the slight favorite after what it accomplished at the World Cup, but this is a talented Spain team with the quality to win.

John Stones, Danny Rose, Jordan Henderson, Eric Dier and Jesse Lingard have all gone on to become key figures under Southgate since facing Spain the last time around, though, and the new-look England came within a whisker of reaching the World Cup final for the first time since 1966 in Russian Federation.

(AAP)England's Luke Shaw goes down after colliding with Spain's Dani Carvajal.

Manchester United left-back Luke Shaw is in no rush to put pen to paper on a new contract at Old Trafford, according to a report.

"I think this does good for everyone", he added.

After the break, Luke Shaw departed the pitch on a stretcher after a awful collision with Dani Carvajal. "I am a fighter, so I will be back soon".

Luke Shaw, making his first global start in three years, was taken off on a stretcher wearing a neck brace and oxygen mask early in the second half after a clash with Dani Carvajal, and the hosts failed to mount a comeback in his absence.