It is a bitter blow for Porte after a broken collarbone in a horrific crash during last year's tour forced him to retire from the race.
His deficit to yellow grew to one minute 42 seconds as Greg Van Avermaet finished second to Degenkolb on the day, two parts of a trio 27 seconds ahead of Froome's group.
But Van Avermaet, who predicted he would lose the yellow jersey before stages Tuesday and Wednesday, cracked on the second of three major climbs Wednesday. "It was a good opportunity and I seized it".
"Everybody said that I was done, after this accident, that I would never come back". When we got closer to the finish I was a bit nervous because of the head wind and I didn't think it was going to happen.
The 25-year-old Groenewegen, who rides for the Dutch Lotto team, flew out of the pack on France's July 14 national holiday to leave Greipel, Gaviria and Sagan trailing in his wake.
The Colombian has been in great form so far and was looking for his third stage win of the race.
This year's crash adds to Porte's rotten luck at the Tour de France.
Frenchman Romain Bardet suffered at least four bike problems, had to change bikes twice and used an enormous amount of energy to somehow limit his time loss to single digits.
"I'm not 100 per cent sure we should be putting cobbled stages in the Tour de France", he said.
A slight brush against Alexander Kristoff saw him sit up, but by then Groenewegen had already gone as the LottoNL-Jumbo rider led home Quick-Step Floors' Fernando Gaviria and Peter Sagan of Bora-Hansgrohe.
BMC's Porte, among the favourites for overall victory, crashed long before the first cobbled sector, just seven kilometres into the 156.5km stage from Arras.
"It's a shame there were not more French in the escape but what can I do, I kept at it and with 50km to go and only a two minutes lead I knew it was impossible, but I plugged on because of the day", said Grellier.
That challenge will be followed by a rest day on Monday before the race shifts to its first mountain stages in the Alps.
In the General classification, van Avermat has maintained its leadership, its separation from British Geraint Thomas (Sky) was increased to 43 seconds.
Russian Federation is a foe in certain aspects. "China is a foe economically, certainly they are a foe", he told CBS. Trump departed for Helsinki on Sunday evening after spending the day playing golf at his private club in Scotland.
They lost the 2016 Euro final 1-0 to Portugal at Stade de France with a roster that included nine holdovers on this year's team. Their playing style may not be attractive, but it was certainly effective and they have made their country very proud.
Rondo averaged 8.3 points and 8.2 assists in helping lead the Pelicans to the Western Conference semifinals last season. However, with a minimum of effort, the Lakers could have a max deal available to lure top-tier free agents next summer.
Great cross for the opener and had looked threatening down the left, but had to go off just before half-time with a muscle injury. It would also see them equal the recent feat of their women's team , who earned bronze at the FIFA Women's World Cup Canada 2015.
Several current Louisville football players expressed on Thursday a desire to have the name of the stadium changed as well. Papa John's latest controversy has begun to cost the brand relationships with baseball teams across the majors.
Common effects of salmonella is the result of a fever, cramps, or diarrhea within 12 to 72 hours of being exposed to the bacteria. The Food and Drug Administration says retails still can not legally sell Kellogg's Honey Smacks cereal following a recall.
I think something is wrong in not just the confirmation process for our court but for lower courts more generally. And in case you're wondering, no, he doesn't support the constitutional mandate for separating church and state .
In fact when Mina climbed in Sterling's back in a bid to halt his progress they actually resembled a jockey carrying his horse. Davinson Sanchez has played day-in, day-out against all of the players likely to be in the England starting eleven.
But Federer went toe to toe with his buoyant opponent in an epic fifth-set tussle until with the score 11-11 Anderson pounced. Djokovic is a three-time victor at Wimbledon , having won the title in 2011, 2014 and 2015. "I think that's not fair".
Kieran Trippier left the Luzhniki pitch in tears against Croatia but his swift return is a major boost for England . Mario Mandzukic then scored the victor in the 109th minute, crushing English hearts everywhere.
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